Dr. Qiong (June) Li, Professor
B.S. Chemistry, Innermongolia Normal University
Ph.D. Organic Chemistry, Northeastern University
Emphases in Molecular Conformation and Activity
It is well-recognized that many 1-arylpiperazines are serotonin agonists, which means they bind to the same binding sites as serotonin and mimic its biological and pharmacological activities. Therefore, simple 1-arylpiperazines represent a structure class that may provide valuable information for finding new serotonin agonists which play an important role in the design of new antidepressants drugs. The goal of my first research project is to use NMR techniques to investigate electronic and steric effects on the conformations of 1-arylpiperazines in solution. A series of 1-arylpiperazines with systematic variation of aryl substituents will be synthesized and investigated by various NMR techniques.
In my second research project, we intend to investigate structure-activity relationships in the cleavage of DNA by arenediazonium salts. A series of arenediazonium salts with various kinds of substituents, different in electronic nature and hydrophilic nature, on the phenyl ring will be synthesized and their activities for DNA cleavage will be investigated. A more efficient DNA cleaving reagent may be obtained through this research.