Professor Chanaka Mendis  

Dr. Chanaka Mendis, Professor

B.S. Chemistry, State University of New-York/Old Westbury

Ph.D. Chemistry, Georgetown University


Publications

1.      Wu, T, Abrahim, A., Mendis, C., and Oldmixon R.  (1993).  Production Mechanism of H* in the He (23S) + CH2Cl2 Reaction, Chemical and Physics Letters, 210:118-122.

2.      Das, R., Mendis, C., Yan, Z., Neil, R, Boyle, T., and Jett M. (1998). Alterations in Gene Expression Show Unique Patterns in Response to Toxic Agents, 21st Army Science Conference, Proceedings 21:529-534.

3.      Das, R., Hammamieh, R., Neil, R., Ludwig, G., Mendis, C., Hoover, D., Dhokalia, A.         Cummings, C. Paranavitana, C., Yang, D.C.H., Lindler, L., Huang, X., Henchal, E. and Jett, M. (2003). Host Gene Expression Profiles In Peripheral Blood Mononuclear Cells:  Detection of Exposure to Biological Threat Agents, Proceedings of the 23rd Army Science Conference, KO-04
(p 1-7).

4.      Das, R., Cummings, C., Mendis, C., Neill, R., Ludwig, G., Hoover, D., Paranavitana, C., Yang, D., Lindler, L., Huang, X., Henchal, E., and Jett, M. (2002). Global Gene Analysis of Various Biological Threat and Infectious Agents Using PBMC:  Implications for Therapy and Rapid Diagnostics, In:  Dianne McQuestion (ed) Report #A029304, Proceedings, Chemical and Biological Defense Symposium.  

5.      Hammamieh, R.,   Das, R.,  Neill, R.,  Mendis, C.,  Bi, S.,  Mani S., Jett, M.  (2004). Host Gene Expression Responses to Bio-Threat and Infectious Agents: Implications for Mathematical Modeling of In Vitro Responses in NATO Medical Surveillance and Response, Research and Technology Opportunities and Options, Human Factors in Medicine, RTO-MP-HFM-108:24-32.

  1. Mendis, C., Das, R., and Jett, M. (2003). Gene Expression Studies in Lymphoid Cells Using DD-PCR (Section I, Chapter 3): Perspectives in Gene Expression Krishnarao Appasani (ed).   Eaton Publications, Westboro, MA.  

  2. Jett, M., Das, R., Cummings, C., Mendis, C., Neill, R., Hoover, D., Lindler, L., Paranavitana, C., Huang, X., Ludwig, G., Henchal, E., Yang, D. (2001). Identification of Changes In Gene Expression Induced By Toxic Agents: Implications for Therapy and Rapid Diagnosis In: Human Factors in Medicine Wade (ed).,  NATO Conference: Operational Medical Issues in Chemical and Biological Defense, RTO-MP-075 19-1 to 19-8.2002.
  3. Hammamieh, R., Bi, S., Mani, S., Chakraborty, N., Mendis, C., Das, R., and Jett, M. (2003). Genetic Variation in Peripheral Blood Mononuclear Cells in Piglets Used as an Animal Model for Staphylococcal Enterotoxins Exposures, Omics, 7 (4) 401-409.
  4. Mendis, C. Das R., Royaee, A., Hammamieh, R., Peel, S., Yang D and Jett, M. Transcriptional Response Signature of Human Lymphoid Cells to Staphyloccocus Aureous Enterotoxin B. (2005). Genes & Immunity, 6, 84-94.
  5.  Royaee, A., Hammamieh, R., Mendis, C., Das, R., Jett, M., and Yang D. (2006).  Induction of   Immunomodulator Transcriptional Responses by Cholera ToxinMol Immunol. March 43(7): 1020-8.
  6. Royaee, A. R., Jong, L., Mendis, C., Das, R., Jett, M. and Yang, D. C. H., (2006). Cholera Toxin Induced Novel Genes in Human Lymphocytes and Monocytess.  Mol Immunol. March 43(8): 1267-74.
  7. Royaee, A. R., Mendis, C., Das R.,  Jett, M., and Yang, D.C., (2006). Cholera Toxin Induced Gene Expression Alterations. Mol Immunol. February 43(6): 702-9.
  1. Das, R., Hammamieh, R., Neill, R., Ludwig, G. V., Lincoln, E. S., Ramamoorthy, P., Dhokalia, A.,  Mani, S.,  Mendis, C., Cummings, C., Kearney, B., Royaee, A., Huang, X.Z. Paranavitana, C., Smith, L., Peel, S., Kanesa-Thasan, N., Hoover, D., Lindler, L.E., Yang, D., Henchal, E. and Jett, M., (2008).  Early Indicators of Exposure to Biological Threat Agents Using Host Gene Profiles in Peripheral Blood Mononuclear Cells.  Bio Med Central (BMC) Infectious Diseases. 8:104.
  2. Mendis, C., Campbell, K.*, Das, R., Yang, D. and Jett, M., (2008).   Effect of 5-Lipoxygenase Inhibitor MK591 on Early Molecular and Signaling Events Induced by Staphylococcal Enterotoxin B (SEB) in Human Peripheral Blood Mononuclear Cells (PBMCs). FEBS Journal, 275 3088-3098.
  3. Theoretical Aspects of Secondary Structure (short assay)- Mendis, C, Molecular Life Sciences: An Encyclopedic Reference  Article ID: 333539  Chapter ID: 9 Ellis Bell and Springer, October 2012
  4. Differentiating Gene Expression profile of Staphylococcal Enterotoxin B and Lipopolysaccharide induced human PBMCs, Linebach, M*, Murphy, M*, Hiner M*,  Staab R*,  Jett M.,  and Mendis C., (Under Review, International Journal of Genomic Medicine, July 2014)
  5. Evaluating Multiple Signaling Activities in LPS Induced Human Peripheral Blood Mononuclear Cells, Zindel  K.,* Whiteman S.,* Stapleton S.,* Jett M., Mendis C., (Under preparation)

 

Experience in Supervising Students – Undergraduate Level

Department of Chemistry & Engineering Physics, UW-Platteville, Platteville, WI 53818

Published Student Abstracts

1.       Schiefebein, E*., Turner, A*., Jett, M., and Mendis, C., (2006), Targeting Key Components That Effectively Block LPS Induced Aberrant Cellular Behavior, The FASEB Journal, 20, A933.

2.      Hiner, M *., Lehr, R*., Chakraboorthy, N., Jett, M., and Mendis, C., (2006), Genetic Comparison of SEB to LPS for Rapid Diagnostics The FASEB Journal, 20, A911

3.      Freehauf, E*., Jett, M., Mendis, C., (2006), Conformational analysis of a set of selectively screened apoptotic related genes in a SEB induced human PBMC module, The FASEB Journal, 20, A119

4.      Campbell, K*., Maliborski, S*., Jett, M., and Mendis, C., (2006), Gene Expression Patterns and Pathway Functions of SEB Induced human lymphoid cells, The FASEB Journal, 20, A934

5.      Freehauf, E*., Mason, T*., Presiado, R., and Mendis, C., (2007), Genetic   Variation Within Populations of Brittle Star species in the Sea of Cortez, The FASEB Journal, 21, 501.1

6.      Turner, A*., Whiteman, S*., Jett, M., and Mendis, C., (2007), Early Intervention by Targeting Inhibitors of Multiple Signal Transduction Pathways in LPS Induced Human PBMCs, The FASEB Journal, 21, 664.4

7.      Campbell, K*., Zahrte, M*., Jett, M., and Mendis, C., (2008),Gene Expression Patterns and Pathway Functions of SEB Induced human PBMC, The FASEB Journal, 22, 829.4

8.      Whiteman, S*., Stapleton, S*., Jett, M., and Mendis, C., (2008), Evaluating Multiple Signaling Activities in LPS Induced Human PBMCs, The FASEB Journal, 22, 829.1

9.      Tricia Mason*, Aaron Hopkins*, and Chanaka Mendis, (2009), Effect of SB203580 on apoptosis related gene expression pattern of SEB in human PBMCs, The FASEB J. 2009 23:530.4

10.  Lillege, C*, Zindel, K*., and Chanaka  Mendis, Effect of pathway-interconnectors in SEB induced apoptosis related events in human PBMCs, The FASEB J. 2009 23:526.9

11.  Bandle*, Hildebrandt*, Jett, and Mendis, Gene expression profile of Staphylococcal Enterotoxin B and Lipopolysaccaride induced human PBMCs, The FASEB J. 2010 24:490.1

12.  Lillge*, Klein*, Zindel*, and Mendis, Effect of Pathway-Interconnectors in SEB Induced Apoptosos Related Events in Human PBMCs, The FASEB J. 2010 24:485.17

13.  Kristin Zindel*, Kurstin Wiewel*, Meghan McGivern*, Chanaka Mendis, and Marti Jett, Early Intervention by Targeting inhibitors of Multiple Signal Transduction Pathways in LPS induced Human PBMCs FASEB J, 2011 25:961.6

14.  Rebecca Klein*, Sarah Daily*, Marti Jett, and Chanaka Mendis, Effect of pathway-interconnectors in SEB-induced apoptosis related events in human PBMCs, FASEB J, 2011 25:943.15

15.  Emily Anne Banwarth*, Heather Schneider*, and Chanaka Mendis, Effect of pathway-interconnectors in SEB induced apoptosis related events in human PBMCs FASEB J March 29, 2012 26:761.16,

16.  Meghan McGivern*, Kurstin Wiewel*, Ashley Borkovec*, Marti Jett, and Chanaka Mendis, Evaluating multiple signaling activities in LPS induced human peripheral blood mononuclear cells FASEB J March 29, 2012 26:761.8

17.  Casey Sondgeroth*, Lisa Hesse*, Alyssa Allbaugh*, Chanaka Mendis, and Marti Jett, Gene Expression Analysis to Evaluate the Effect of p38 Specific Inhibitor SB203580 on SEB-Induced Apoptosis Related Pathways FASEB J April 9, 2013 27:604.6

18.  James Waldschmidt*, James Kivel*, Melissa Wielnau*, and Chanaka Mendis

Effect of pathway-interconnectors in SEB-induced apoptosis related events in human PBMCs (609.19) FASEB J April 2014 28:609.19

Selected Student Poster Presentations (Presented in 2005 to present)

  1. “Gene Expression Patterns and Pathway Functions of SEB Induced Human PBMCs,”  Katherine Campbell*1, Darin Zharte*1, Marti Jett2 and Chanaka Mendis1, 1Department of Chemistry and Engineering Physics, UW-Platteville, 1 University Plaza, Platteville, WI 53818, 2Walter Reed Army Institute of Research, Department of Molecular Pathology, Silver Spring MD 20910, American Society for Biochemistry and Molecular Biology (ASBMB) Conference, San Diego, CA, April 2008
  2. Early Intervention by Targeting Inhibitors of Multiple Signal Transduction Pathways in LPS Induced Human PBMCs,” Sarah Whiteman*1, Suzanne Stapleton*1, Marti Jett2 and Chanaka Mendis1, 1Department of Chemistry and Engineering Physics, UW-Platteville, 1 University Plaza, Platteville, WI 53818, 2Walter Reed Army Institute of Research, Department of Molecular Pathology, Silver Spring, MD 20910, ASBMB Conference, San Diego, CA, April 2008.
  3. “Changes in Gene Host Expression Induced by Venezuelan Equine Encephalitis (VEE) in Blood Samples From Humans Using Real Time PCR,” Sarah Whiteman*1, and Mohsen Barmada2, 1Department of Chemistry and Engineering Physics, UW-Platteville, 1 University Plaza, Platteville, WI 53818, 2Walter Reed Army Institute of Research, Department of Molecular Pathology, Silver Spring, MD 20910, Annual WRAIR Science and Engineering Apprentice Program (SEAP) / College and Qualified Leaders Symposium (CQL), Washington DC, August 2007.
  4. “Early Intervention by Targeting Inhibitors of Multiple Signal Transduction Pathways in LPS Induced Human PBMCs,” Anne Turner*1, Sarah Whiteman*1, Marti Jett2   and Chanaka Mendis1, 1Department of Chemistry and Engineering Physics, UW-Platteville, 1 University Plaza, Platteville, WI 53818, 2Walter Reed Army Institute of Research, Department of Molecular Pathology, Silver Spring, MD 20910, ASBMB Conference, Washington DC, May 2007.
  5. “Genetic Variation Within Populations of Brittle Star Species in the Sea of Cortez,” Emily A. Freehauf*1, Tricia Mason*1, Rhea Presiado1 and Chanaka Mendis2, 1Department of Social Sciences and Geography, UW-Platteville, 1 University Plaza, Platteville, WI 53818, 2Department of Chemistry and Engineering Physics, UW-Platteville, 1 University Plaza, Platteville, WI 53818, ASBMB Conference, Washington DC, May 2007.
  6. “Genetic Comparison of SEB to LPS for Rapid Diagnostics,” Mark Hiner*1, Rachael Lehr*1, Nabarun Chakraborty2, Marti Jett2 and Chanaka Mendis1, 1Department of Chemistry and Engineering Physics, UW-Platteville, 1 University Plaza, Platteville, WI 53818, 2Walter Reed Army Institute of Research, Department of Molecular Pathology, Silver Spring, MD 20910, ASBMB Conference, San Francisco, CA, April 2006.
  7. “Conformational Analysis of a Set of Selectively Screened Apoptotic Related Genes in a SEB Induced Human PBMC Module,” Emily A. Freehauf*1, Chanaka Mendis1, Marti Jett2, 1Department of Chemistry and Engineering Physics, UW-Platteville, 1 University Plaza, Platteville, WI 53818, 2Walter Reed Army Institute of Research, Department of Molecular Pathology, Silver Spring, MD, ASBMB Conference, San Francisco, CA, April 2006.
  8. “Diagnostic Targets of SEB Induced Human Peripheral Blood Mononuclear Cells,” Katherine Campbell*, Sarah Maliborski* and Chanaka Mendis,  6th Annual UW Symposium for Undergraduate Research & Creativity, Oshkosh, WI, 54904, April 2005.

All Undergraduate students have been identified with a symbol

Department of Chemistry 
University of Wisconsin-Platteville
1 University Plaza
Platteville, WI 53818

Office: 100 Ottensman Hall
Phone: (608) 342-1692
FAX: (608) 342-1566

Email: mendisc@uwplatt.edu